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How Does Zolpidem Help People Sleep? Zolpidem has a similar mechanism of action to benzodiazepines in that it increases the ambien actions of the neurotransmitter gamma-aminobutyric acid (GABA) at GABAA receptors in the brain (Nutt & Stahl, 2010) .
ambien GABAA receptors have an inhibitory effect on neural transmission within the brain .
Extra stimulation of these receptors can lead to the onset of ambien sleep .

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